منابع مشابه
SnapShot: Lung Cancer Models
K-ras activation K-rasLSL-G12D or K-rasLSL-G12V Cre-dependent expression of oncogenic K-rasG12D or K-rasG12V from endogenous locus. Viral cre delivery via adenoviral or lentiviral inoculation (intranasal or intratracheal). Adenocarcinoma spectrum histology (i.e., in situ and invasive neoplasia) in lung; metastasis not reported. K-ras somatic mutations identified in ~20%30% of lung adenocarcinom...
متن کاملSnapShot: Genetic Mouse Models of Cancer
p 53 T um o r S up p re ss o r Trp53 mouse germline knockout. Trp53−/− homozygous: 100% tumor penetrance at ?4.5 months. Typical tumors: T cell lymphoma (>60%); soft tissue sarcoma (?25%); osteosarcoma, brain tumors, teratoma (together <15%); carcinomas rarely observed. Trp53+/− heterozygous: 50% tumor penetrance at 17 months. Typical tumors: T cell lymphoma (?30%); soft tissue sarcoma (?30%); ...
متن کاملZiegler Wax Embryo Models
Three-dimensional anatomical models have long been essential to the learning of science and lend a sense of ?control? to those practicing in the field. As the development of embryology [4] grew in importance during the late 1800s, so did the need for models to show intricate details of embryos. Embryologists such as Wilhelm His [5], Ernst Haeckel [6], and Oscar Hertwig all initially constructed...
متن کاملEmbryo Blotting Paper Models
Anatomical models have always been a mainstay of descriptive embryology [5]. As the training of embryologists grew in the late 1800s, so too did the need for large-scale teaching models. Embryo wax models, such as those made by Adolf Ziegler [6] and Gustav Born [7], were popular in the latter part of the nineteenth century and the early twentieth century as a way to visualize, in three dimensio...
متن کاملOpen Problem: Learning Dynamic Network Models from a Static Snapshot
In this paper we consider the problem of learning a graph generating process given the evolving graph at a single point in time. Given a graph of sufficient size, can we learn the (repeatable) process that generated it? We formalize the generic problem and then consider two simple instances which are variations on the well-know graph generation models by Erdős-Rényi and Albert-Barabasi. 1. Prob...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2021
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2021.04.012